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Resource center Editor

Aristides Tsatsakis University of Crete
Laboratory of Toxicology and Forensic Chemistry
Irakleio, Greece
Professor Tsatsakis reports no conflicts of interest with the content of this resource center.

About this resource center

The Research Institute for Fragrance Materials (RIFM) has partnered with Elsevier on the Food and Chemical Toxicology Fragrance Material Safety Assessment Center to provide open access to RIFM’s peer-reviewed Safety Assessments and related papers and research.

RIFM Safety Assessments are written according to the guidelines outlined in the Criteria for the Research Institute for Fragrance Materials (the “Criteria Document”) safety evaluation process for fragrance ingredients. The Criteria Document provides guidance on conducting safety assessments and is designed to incorporate the best science to appropriately evaluate fragrance ingredients using the latest testing strategies and methods.

The assessments may be found by using the search feature above. Group Studies and Background Studies that predate the Criteria Document may be found in the Historical Data section below.

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For more information on RIFM, visit www.rifm.org.


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Criteria Document

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety Evaluation Process for Fragrance Ingredients Api AM, Belsito D, Bruze M, et al

This Criteria Document details recent updates to the RIFM safety assessment process, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past 10 years.

These changes include incorporating:
  • New scientific information including a framework for choosing structural analogs
  • Consideration of the Threshold of Toxicological Concern (TTC)
  • Quantitative Risk Assessment (QRA) for dermal contact sensitization
  • Respiratory route of exposure
  • Aggregate exposure assessment methodology
  • Latest methodology and approaches to risk assessments
  • Latest alternatives to animal testing methodology
  • Environmental risk assessment

Historic Data

Background Studies
The Safety Assessment of Fragrance Materials

Bickers DR, Calow P, Greim HA, et al

Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information.

Criteria for Development of a Database for Safety Evaluation of Fragrance Ingredients

Ford RA, Domeyer B, Easterday O, et al

Over 2000 different ingredients are used in the manufacture of fragrances. The majority of these ingredients have been used for many decades.

Consumer Exposure to Fragrance Ingredients: Providing Estimates for Safety Evaluation

Peter A. Cadby, William R. Troy, Matthias G. H. Vey

To fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints.

About RIFM Safety Assessments

Information for reviewers image description

Introduction to RIFM Safety Assessments

RIFM evaluates available data and sponsors studies for relevant toxicological endpoints for local and systemic human health effects, including genotoxicity, repeated dose and reproductive toxicity, skin sensitization, photoirritation/photoallergenicity, and local respiratory toxicity. RIFM also sponsors testing and academic research on the fate and effects of fragrance materials in water, soil, sediments, and air, working closely with international research organizations to assess the behavior and risk of chemicals in the environment.

RIFM compiles its findings, along with other relevant data, into Safety Assessments for each material currently in use by the fragrance industry. The Expert Panel for Fragrance Safety, an independent, international team of researchers and academics with no ties to the fragrance industry, reviews and must approve all of RIFM’s Safety Assessments before RIFM submits them for peer-reviewed publication.

RIFM Safety Assessments are dynamic, “living” documents, and RIFM reevaluates materials on a rolling five-year basis to help ensure safe conditions of use. When a Safety Assessment is updated and published, only the most up-to-date version will be available on this resource center. (Previous versions of the safety assessments will always be available on the Food and Chemical Toxicology site or from Science Direct.) A list of RIFM safety assessments that have been reviewed with no changes will also appear on this resource center.

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