Api AM, Belsito D, Bruze M, et al
This Criteria Document details recent updates to the RIFM safety assessment process, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past 10 years. These changes include incorporating:
- New scientific information including a framework for choosing structural analogs
- Consideration of the Threshold of Toxicological Concern (TTC)
- Quantitative Risk Assessment (QRA) for dermal contact sensitization
- Respiratory route of exposure
- Aggregate exposure assessment methodology
- Latest methodology and approaches to risk assessments
- Latest alternatives to animal testing methodology
- Environmental risk assessment