RIFM Home

For more information about the Research Institute for Fragrance Materials, visit www.rifm.org.

New Webinar

Click here to learn more about the Creme RIFM Aggregate Exposure Model and the Quantitative Risk Assessment (QRA2). Learn how QRA2 changed from QRA1, how we use the Creme RIFM Model in the QRA2 and how the Creme RIFM Aggregate Exposure Model is used to derive Maximum Acceptable Concentrations based on all toxicological endpoints in the RIFM Safety Assessments.

Criteria Document

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety Evaluation Process for Fragrance Ingredients

Api AM, Belsito D, Bruze M, et al

This Criteria Document details recent updates to the RIFM safety assessment process, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past 10 years. These changes include incorporating:

New scientific information including a framework for choosing structural analogs
Consideration of the Threshold of Toxicological Concern (TTC)
Quantitative Risk Assessment (QRA) for dermal contact sensitization
Respiratory route of exposure
Aggregate exposure assessment methodology
Latest methodology and approaches to risk assessments
Latest alternatives to animal testing methodology
Environmental risk assessment

The Safety Assessment of Fragrance Materials

Bickers DR, Calow P, Greim HA, et al

Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information.

READ MORE
Criteria for Development of a Database for Safety Evaluation of Fragrance Ingredients

Ford RA, Domeyer B, Easterday O, et al

Over 2000 different ingredients are used in the manufacture of fragrances. The majority of these ingredients have been used for many decades.

READ MORE
Consumer Exposure to Fragrance Ingredients: Providing Estimates for Safety Evaluation

Peter A. Cadby, William R. Troy, Matthias G. H. Vey

To fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints.

READ MORE

Additional Reading

A framework for prioritizing fragrance materials for aquatic risk assessment.

Salvito DT, Senna RJ, Federle TW. Environ Toxicol Chem. 2002;21:1301-1308.

READ MORE
Design and feasibility of an international study assessing the prevalence of contact allergy to fragrances in the general population: The European Dermato-Epidemiology Network Fragrance Study.

Rossi M, Coenraads PJ, Diepgen T, et al. Dermatology. 2010;221:267-275.

READ MORE
Prevalence of self-reported skin complaints and avoidance of common daily life consumer products in selected European Regions.

Naldi L, Cazzaniga S, Gonçalo M, et al. JAMA Dermatol. 2014;150:154-163.

READ MORE

Subscribe to Receive Updates

Register here to be notified when new Safety Assessment Sheets are added to this site. Your email address will only be used to notify you of updates to this site. You may opt out at any time.

Feature Articles

Integrating Habits and Practices Data for Soaps, Cosmetics and Air Care Products into an Existing Aggregate Exposure Model

Comiskey D, Api AM, Barrett C, et al

In order to accurately assess aggregate exposure to a fragrance material in consumers, data are needed on consumer habits and practices, as well as the concentration of the fragrance material in those products.

READ MORE
Application of the Expanded Creme RIFM Consumer Exposure Model to Fragrance Ingredients in Cosmetic, Personal Care and Air Care Products

Safford B, Api AM, Barrett C, et al

As part of a joint project between the Research Institute for Fragrance Materials (RIFM) and Crème Global, a Monte Carlo model (here named the Creme RIFM model) has been developed to estimate consumer exposure to ingredients in personal care products.

READ MORE
Novel Database for Exposure to Fragrance Ingredients in Cosmetics and Personal Care Products

Comiskey D, Api AM, Barratt C, et al

Exposure of fragrance ingredients in cosmetics and personal care products to the population can be determined by way of a detailed and robust survey.

READ MORE
Use of an Aggregate Exposure Model to Estimate Consumer Exposure to Fragrance Ingredients in Personal Care and Cosmetic Products

Safford B, Api AM, Barratt C, et al

Ensuring the toxicological safety of fragrance ingredients used in personal care and cosmetic products is essential in product development and design, as well as in the regulatory compliance of the products.

READ MORE
Extension of the Dermal Sensitisation Threshold (DST) Approach to Incorporate Chemicals Classified as Reactive

Safford RJ, Api AM, Roberts DW, Lalko JF

The evaluation of chemicals for their skin sensitising potential is an essential step in ensuring the safety of ingredients in consumer products.

READ MORE
Principles for identification of High Potency Category Chemicals for Which the Dermal Sensitisation Threshold (DST) Approach Should Not be Applied

Roberts DW, Api AM, Safford RJ, Lalko JF

An essential step in ensuring the toxicological safety of chemicals used in consumer products is the evaluation of their skin sensitising potential.

READ MORE
Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients

Api AM, Basketter DA, Cadby PA, et al

Based on chemical, cellular, and molecular understanding of dermal sensitization, an exposure-based quantitative risk assessment (QRA) can be conducted to determine safe use levels of fragrance ingredients in different consumer product types.

READ MORE
Implementation of the Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients

Api AM, Vey M

Significant developments have recently been incorporated in the way dermal sensitization risk assessments are conducted for fragrance ingredients.

READ MORE
The Research Institute for Fragrance Materials’ Human Repeated Insult Patch Test Protocol

Politano VT, Api AM

With implementation of the dermal sensitization QRA approach for fragrance ingredients, IFRA/RIFM are recommending use of the RIFM standard human repeated insult patch test (HRIPT) protocol for generation of confirmatory human data for the induction of dermal sensitization in a normal human population.

READ MORE

About Safety Assessments

Webinars

Evolution and Innovation in Fragrance Safety Assessment: RIFM at 50

Click here to learn about 50 years of innovation in the safety assessment of raw fragrance matials, the role of RIFM’s Expert Panel, and the latest method of calculating aggregate exposure in consumers.

Assessing the Safety of Fragrance Materials: What are the Criteria?

Click here to join a panel of experts as they detail the latest updates to the criteria used to evaluate the safety of fragrance ingredients.

Previously Published Safety Assessments

Group Summaries

Monographs

Prior to 2003, RIFM produced over 1,000 safety assessment monographs. Click here for a listing of these publications.